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The role of allergen‐specific T cells in the allergic immune response: relevance to allergy vaccination
Author(s) -
Van Neerven Rjj
Publication year - 1999
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.1999.t01-1-00092.x
Subject(s) - allergy , immunology , allergen , medicine , immune system , allergic response , immunoglobulin e , eosinophilia , vaccination , antibody
Recent research has elucidated many of the immunologic mechanisms that underlie atopic allergies. In particular, it has become clear that the role of CD4 + allergen‐specific T cells is crucial for the induction of IgE and eosinophilia, factors that mediate the immediate hypersensitivity reaction and late‐phase responses, respectively. Therefore, the reactivity patterns and activation requirements of allergen‐specific T cells are important parameters for understanding and manipulating the allergic immune response. This review addresses these issues and discusses their relevance to the further development of allergy vaccines.