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Nerve growth factor release with mast‐cell‐derived mediators in a patient with systemic mastocytosis after middle‐wave ultraviolet irradiation
Author(s) -
Kurosawa M.,
Inamura H.,
Amano H.,
Kanbe N.,
Nagata H.,
Nagai H.,
Furukawa S.,
Miyachi Y.
Publication year - 1999
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1034/j.1398-9995.1999.00204.x
Subject(s) - mast cell , stem cell factor , peripheral blood mononuclear cell , ultraviolet light , systemic mastocytosis , nerve growth factor , immunology , medicine , biology , chemistry , microbiology and biotechnology , stem cell , receptor , haematopoiesis , biochemistry , in vitro , photochemistry
Background: The symptoms of a 56‐year‐old man with systemic mastocytosis became worse with exposure to sunlight. We evaluated mast‐cell‐derived mediators and cytokines before and after exposure to ultraviolet light in the patient. Methods: The patient was irradiated with middle‐wave ultraviolet light, so‐called ultraviolet light B, and the levels of mediators and cytokines were measured serially. The point mutation Asp816Val in c‐ kit was investigated by analyzing polymerase chain reaction products from the complementary DNA of peripheral blood mononuclear cells. Results: Before irradiation, the levels of mast‐cell‐derived mediators and metabolites were elevated. Among various cytokines measured, including soluble c‐ kit and stem cell factor, only the level of nerve growth factor was elevated. After irradiation, the nerve growth factor level was further increased along with the levels of mast‐cell‐derived mediators and metabolites. The point mutation Asp816Val in c‐ kit was not detected in peripheral blood mononuclear cells. Conclusions: Middle‐wave ultraviolet light may activate mast cells to release nerve growth factor and mediators in systemic mastocytosis.