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Stability of malonylcarnitine and glutarylcarnitine in stored blood spots
Author(s) -
Johnson D. W.,
Trinh> M.U.
Publication year - 2004
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/b:boli.0000045830.82698.90
Subject(s) - spots , dried blood , chromatography , tandem mass spectrometry , whole blood , chemistry , mass spectrometry , medicine , surgery , pathology
Summary: Malonylcarnitine and glutarylcarnitine are important diagnostic metabolites in the screening of dried blood spots by tandem mass spectrometry. The stability of these compounds in spiked blood spots stored at room temperature was studied. Both showed biphasic curves. The malonylcarnitine concentration dropped to 61% in 38 days and averaged 51%±5% for the next 81 days. Glutarylcarnitine dropped to 60% in 42 days and averaged 56%±5% for the next 124 days.