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Neuroleptic malignant syndrome in juvenile neuronal ceroid lipofuscinosis associated with low‐dose risperidone therapy
Author(s) -
Vercammen L.,
Buyse G. M.,
Proost J. E. F.,
Van Hove J. L. K.
Publication year - 2003
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1025916518457
Subject(s) - risperidone , medicine , psychosis , neuroleptic malignant syndrome , adverse effect , dopaminergic , extrapyramidal symptoms , juvenile , dopamine , pediatrics , psychiatry , schizophrenia (object oriented programming) , antipsychotic , biology , genetics
Summary: #We present a patient with juvenile neuronal ceroid lipofuscinosis who developed a neuroleptic malignant syndrome when treated for hallucinations with a very low dose of risperidone, an atypical neuroleptic medication with usually few extrapyramidal side‐effects. The loss of dopaminergic neurons in this condition may make these patients more vulnerable to this severe adverse effect.