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Diffusion‐weighted imaging in the assessment of neurological damage in patients with methylmalonic aciduria
Author(s) -
Burlina A. P.,
Manara R.,
Calderone M.,
Catuogno S.,
Burlina A. B.
Publication year - 2003
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1025106909213
Subject(s) - methylmalonic aciduria , medicine , magnetic resonance imaging , brain damage , encephalopathy , diffusion mri , methylmalonic acid , radiology , pathology , homocysteine
Diffusion‐weighted magnetic resonance imaging (DW‐MRI) of the brain was performed in two patients with methylmalonic aciduria who presented signs and symptoms of neurological involvement without metabolic decompensation. Patient 1 presented acute metabolic stroke and patient 2 presented subacute encephalopathy. Brain DW‐MRI confirmed very recent damage in patient 1, while the absence of brain lesions on brain DW‐MRI indicates the development of more chronic damage in patient 2. Brain DW‐MRI represents an additional and complementary tool in the assessment of brain damage in methylmalonic aciduria patients who develop neurological syndrome.