Premium
Allopurinol challenge tests performed before and after living‐related donor liver transplantation in citrullinaemia
Author(s) -
Ito T.,
Sumi S.,
Kidouchi K.,
Ban K.,
Ueta A.,
Hashimoto T.,
Togari H.,
Wada Y.
Publication year - 2003
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1024096001455
Subject(s) - allopurinol , medicine , transplantation , liver transplantation , gastroenterology
Summary: We performed allopurinol challenge tests to evaluate the metabolic state of a citrullinaemic patient who received a living‐relative donor liver transplant. Before transplantation, large amounts of orotic acid and orotidine were excreted during the challenge test. Following transplantation, excretion of these compounds in response to allopurinol was normalised. The challenge test was a safe and useful method to evaluate the metabolic state of the patient.