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Complex Genetic Disorders: Evaluating When Genetic Research Findings Are Applicable for Genetic Counseling Practice
Author(s) -
Wolpert Chantelle M.,
Melvin Elizabeth C.,
Speer Marcy C.
Publication year - 1999
Publication title -
journal of genetic counseling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 52
eISSN - 1573-3599
pISSN - 1059-7700
DOI - 10.1023/a:1022843530795
Subject(s) - genetic counseling , realm , genetic testing , task (project management) , human genetics , disequilibrium , psychology , computer science , management science , clinical psychology , medicine , genetics , biology , management , political science , gene , ophthalmology , law , economics
Traditional genetic counseling processes and principles will be extended to a new realm—complex disorders. Although it may seem like a daunting task, understanding the methodologies used to study complex genetic disorders will enable genetic counselors to critically analyze research studies involving complex disorders. In this article, we explain newly evolving methodologies for genetic research, including case‐control studies and transmission disequilibrium testing (TDT). Additionally, a framework is provided for evaluating original research findings and replication studies.