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Genetic Counseling and Screening of Consanguineous Couples and Their Offspring: Recommendations of the National Society of Genetic Counselors
Author(s) -
Bennett Robin L.,
Motulsky Arno G.,
Bittles Alan,
Hudgins Louanne,
Uhrich Stefanie,
Doyle Debra Lochner,
Silvey Kerry,
Scott C. Ronald,
Cheng Edith,
McGillivray Barbara,
Steiner Robert D.,
Olson Debra
Publication year - 2002
Publication title -
journal of genetic counseling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.867
H-Index - 52
eISSN - 1573-3599
pISSN - 1059-7700
DOI - 10.1023/a:1014593404915
Subject(s) - genetic counseling , medical genetics , medicine , family medicine , consanguinity , public health , newborn screening , consanguineous marriage , human genetics , ethnic group , psychosocial , offspring , pregnancy , pediatrics , psychiatry , genetics , nursing , sociology , biology , anthropology , gene
Abstract The objective of this document is to provide recommendations for genetic counseling and screening for consanguineous couples (related as second cousins or closer) and their offspring with the goals of 1. providing preconception reproductive options 2. improving pregnancy outcome and identifying reproductive choices 3. reducing morbidity and mortality in the 1st years of life, and 4. respecting psychosocial and multicultural issues. The recommendations are the opinions of a multicenter working group (the Consanguinity Working Group (CWG)) with expertise in genetic counseling, medical genetics, biochemical genetics, genetic epidemiology, pediatrics, perinatology, and public health genetics, which was convened by the National Society of Genetic Counselors (NSGC). The consensus of the CWG and NSGC reviewers is that beyond a thorough medical family history with follow‐up of significant findings, no additional preconception screening is recommended for consanguineous couples. Consanguineous couples should be offered similar genetic screening as suggested for any couple of their ethnic group. During pregnancy, consanguineous couples should be offered maternal–fetal serum marker screening and high‐resolution fetal ultrasonography. Newborns should be screened for impaired hearing and detection of treatable inborn errors of metabolism. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a health care provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.