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Treatment of late‐onset nonketotic hyperglycinaemia: Effectiveness of imipramine and benzoate
Author(s) -
Wiltshire E. J.,
Poplawski N. K.,
Harrison J. R.,
Fletcher J. M.
Publication year - 2000
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1005690611675
Subject(s) - imipramine , medicine , placebo , sodium benzoate , pediatrics , anesthesia , pathology , alternative medicine
We report a patient with late‐onset nonketotic hyperglycinaemia managed with a sequential approach to drug therapy in placebo‐controlled therapeutic trials. Partial response to low‐protein diet and sodium benzoate and dramatic response to imipramine are demonstrated, with parental scores on the Developmental Behavioural Checklist falling from the 86th centile before treatment to normal with combined benzoate and imipramine therapy.