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Effect of plasma α‐tocopherol on leukotriene E4 excretion in genetic vitamin E deficiency
Author(s) -
Kohlschütter A.,
Mayatepek E.,
Finckh B.,
Hübner C.
Publication year - 1997
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1005311227094
Subject(s) - vitamin e deficiency , excretion , vitamin e , human genetics , tocopherol , endocrinology , medicine , vitamin , chemistry , biochemistry , antioxidant , gene
Studying the biological effects of vitamin E in humans is difficult because conditions involving vitamin E deficiency are usually associated with chronic multiple pathology. Genetic vitamin E deficiency caused by a deficient α‐tocopherol transport protein offers unique possibilities for study of vitamin E effects since the patients can be studied in good general health. In such a patient we manipulated plasma α‐tocopherol levels in a wide range by varying oral α‐tocopherol supplements and measured urinary leukotriene E4 (LTE4) concentrations. LTE4 excretion proved inversely correlated to plasma α‐tocopherol levels. This strongly suggests that in genetic vitamin E deficiency, α‐tocopherol influences formation of leukotrienes in vivo.