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Severe lactic acidosis and neonatal death in Pearson syndrome
Author(s) -
Muraki K.,
Goto Y.,
Nishino I.,
Hayashidani M.,
Takeuchi S.,
Horai S.,
Sakura N.,
Ueda K.
Publication year - 1997
Publication title -
journal of inherited metabolic disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 102
eISSN - 1573-2665
pISSN - 0141-8955
DOI - 10.1023/a:1005305422544
Subject(s) - lactic acidosis , metabolic acidosis , acidosis , pancytopenia , medicine , sideroblastic anemia , metabolic disorder , gastroenterology , endocrinology , physiology , anemia , bone marrow
Abstract Pearson marrow‐pancreas syndrome, a fatal disease associated with mitochondrial DNA rearrangements, is characterized by refractory sideroblastic anaemia during infancy. Only a few neonates with Pearson syndrome have been reported with metabolic acidosis. A female neonate who exhibited severe metabolic acidosis and anaemia at birth is described here. Her condition progressively worsened, with pancytopenia and uncontrollable metabolic acidosis resulting in death at the age of 14 days. A 4988‐base pair deletion of mtDNA was detected in the patient's leukocytes, liver and muscle. When a neonate exhibits severe metabolic acidosis of unknown cause, the possibility of Pearson syndrome should be considered.