Open AccessActivation of Inflammasomes by Agents Causing Idiosyncratic Skin Reactions: A Possible Biomarker
Author(s) -
Jean K. Weston,
Jack Uetrecht
Publication year - 2014
Publication title -
chemical research in toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 156
eISSN - 1520-5010
pISSN - 0893-228X
DOI - 10.1021/tx5001333
Subject(s) - telaprevir , boceprevir , inflammasome , chemistry , drug , immune system , dimethyl fumarate , pharmacology , biochemistry , immunology , medicine , receptor , ribavirin , multiple sclerosis , genotype , gene
Chemically reactive drugs and drugs that form reactive metabolites often cause idiosyncratic drug reactions (IDRs); however, not all such drugs are associated with IDRs. Most IDRs appear to be immune mediated; therefore, the ability of a drug to induce an immune response may be the determinant of which drugs will cause IDRs. Inflammasome activation plays an important role in the initiation of an immune response. In this study, we studied two pairs of similar chemically reactive drugs, telaprevir/boceprevir and dimethyl fumarate/ethacrynic acid. In both pairs, the drug associated with skin reactions activated inflammasomes in THP-1 cells, and the drug not associated with skin reactions did not.