Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts | Zendy

Wolfgang Kroutil | Zendy; EvaMaria Fischereder | Zendy; Christine Fuchs | Zendy; Horst Lechner | Zendy; Francesco G. Mutti | Zendy; Desiree Pressnitz | Zendy; Aashrita Rajagopalan | Zendy; Johann H. Sattler | Zendy; Robert C. Simon | Zendy; Elina Siirola | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

Author(s) -

Wolfgang Kroutil,

EvaMaria Fischereder,

Christine Fuchs,

Horst Lechner,

Francesco G. Mutti,

Desiree Pressnitz,

Aashrita Rajagopalan,

Johann H. Sattler,

Robert C. Simon,

Elina Siirola

Publication year - 2013

Publication title -

organic process research and development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 109

eISSN - 1520-586X

pISSN - 1083-6160

DOI - 10.1021/op4000237

Subject(s) - primary (astronomy) , kinetic resolution , chemistry , enantioselective synthesis , regioselectivity , ring (chemistry) , enantiomeric excess , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , physics , astronomy

This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primary amines from the corresponding ketones as well as terminal amines from primary alcohols via a two-step biocascade. 2,6-Disubstituted piperidines, as examples for secondary amines, are prepared by biocatalytical regioselective asymmetric monoamination of designated diketones followed by spontaneous ring closure and a subsequent diastereoselective reduction step. Optically pure tert -amines such as berbines and N -methyl benzylisoquinolines are obtained by kinetic resolution via an enantioselective aerobic oxidative C-C bond formation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research