Phorbaketals A, B, and C, Sesterterpenoids with a Spiroketal of Hydrobenzopyran Moiety Isolated from the Marine Sponge Phorbas sp. | Zendy

JungRae Rho | Zendy; Buyng Su Hwang | Zendy; Chung Ja Sim | Zendy; Seewon Joung | Zendy; HeeYoon Lee | Zendy; HyeonJin Kim | Zendy

Open Access

Phorbaketals A, B, and C, Sesterterpenoids with a Spiroketal of Hydrobenzopyran Moiety Isolated from the Marine Sponge Phorbas sp.

Author(s) -

JungRae Rho,

Buyng Su Hwang,

Chung Ja Sim,

Seewon Joung,

HeeYoon Lee,

HyeonJin Kim

Publication year - 2009

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol902223m

Subject(s) - sponge , moiety , chemistry , stereochemistry , cytotoxicity , biochemistry , in vitro , biology , botany

Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral and chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, and lung cancer cell lines. Furthermore, the cultivation of the bacterial fraction from the sponge afforded compound 1.

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