Building Molecular ComplexityviaTandem Ru-catalyzed Isomerization/C−H Activation | Zendy

Agnieszka Bartoszewicz | Zendy; Belén MartínMatute | Zendy

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Building Molecular ComplexityviaTandem Ru-catalyzed Isomerization/C−H Activation

Author(s) -

Agnieszka Bartoszewicz,

Belén MartínMatute

Publication year - 2009

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol900243x

Subject(s) - isomerization , chemistry , tandem , catalysis , allylic rearrangement , tsuji–trost reaction , functional group , alkylation , cascade reaction , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , materials science , polymer , composite material

A tandem isomerization/C-H activation of allylic alcohols was performed using a catalytic amount of RuCl(2)(PPh(3))(3). A variety of ortho alkylated ketones have been obtained in excellent yields. This tandem process relies on an in situ generation of a carbonyl functional group that directs the ortho C-H bond activation.

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