The Taumycin A Macrocycle: Asymmetric Total Synthesis and Revision of Relative Stereochemistry | Zendy

Justine N. deGruyter | Zendy; William A. Maio | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Taumycin A Macrocycle: Asymmetric Total Synthesis and Revision of Relative Stereochemistry

Author(s) -

Justine N. deGruyter,

William A. Maio

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol5025585

Subject(s) - chemistry , ketene , diastereomer , total synthesis , stereochemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , catalysis

The first asymmetric total synthesis and revision of the relative configuration of the 12-membered taumycin A macrocycle is described. Key to the success of this work was a novel α-keto ketene macrocyclization that provided an efficient means by which to access two diastereomers of the desired macrolide without the need to employ additional coupling agents or unnecessary oxidation state adjustments.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research