Open AccessPalladium-Catalyzed Regioselective Arylation of 1,1,3-Triaryl-2-azaallyl Anions with Aryl Chlorides
Author(s) -
Minyan Li,
Simon Berritt,
Patrick J. Walsh
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol502043j
Subject(s) - regioselectivity , chemistry , palladium , isomerization , aryl , yield (engineering) , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl , materials science , metallurgy
A regioselective arylation of 1,1,3-triaryl-2-azaallyl anions with aryl chlorides is described. The palladium-NIXANTPHOS-based catalyst affords diarylmethylamine derivatives in good yield and without product isomerization. A gram scale sequential one-pot ketimine synthesis/arylation protocol was also developed.
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