Open AccessDiastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A
Author(s) -
Angus W. J. Logan,
Simon J. Sprague,
Robert W. Foster,
Léo Marx,
Vincenzo Garzya,
Michal S. Hallside,
Amber L. Thompson,
Jonathan W. Burton
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol501662t
Subject(s) - citation , computer science , library science , information retrieval , world wide web
A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported. The methodology is demonstrated in a formal synthesis of (-)-salinosporamide A.
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