Open AccessCharacterization of a Brain Permeant Fluorescent Molecule and Visualization of Aβ Parenchymal Plaques, Using Real-Time Multiphoton Imaging in Transgenic Mice
Author(s) -
G. S. M. Sundaram,
Kanchan Garai,
Nigam P. Rath,
Ping Yan,
John R. Cirrito,
Nigel J. Cairns,
Lee J,
Vijay Sharma
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol501264q
Subject(s) - chemistry , parenchyma , genetically modified mouse , fluorescence , blood–brain barrier , transgene , molecular imaging , characterization (materials science) , biophysics , pathology , neuroscience , nanotechnology , biochemistry , in vivo , central nervous system , medicine , gene , microbiology and biotechnology , materials science , quantum mechanics , biology , physics
Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer's disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of numerous diffuse Aβ plaques in confirmed AD human brain tissues and traverses the blood-brain barrier to enable labeling of parenchymal Aβ plaques in live mice (APP(±)/PS1(±)) brains.