Open AccessGold-Catalyzed Enantioselective Ring-Expanding Cycloisomerization of Cyclopropylidene Bearing 1,5-Enynes
Author(s) -
Hongchao Zheng,
Ryan J. Felix,
Michel R. Gagné
Publication year - 2014
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol5007955
Subject(s) - cycloisomerization , moiety , enantioselective synthesis , chemistry , ring (chemistry) , stereochemistry , catalysis , structural motif , combinatorial chemistry , organic chemistry , biochemistry
An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products.
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