Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp. | Zendy

Vincent E. Rasamison | Zendy; Liva Harinantenaina | Zendy; Carla Slebodnick | Zendy; Peggy J. Brodie | Zendy; Michel Ratsimbason | Zendy; Karen TenDyke | Zendy; Yongchun Shen | Zendy; Lucien M. Randrianjanaka | Zendy; David G. I. Kingston | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

Author(s) -

Vincent E. Rasamison,

Liva Harinantenaina,

Carla Slebodnick,

Peggy J. Brodie,

Michel Ratsimbason,

Karen TenDyke,

Yongchun Shen,

Lucien M. Randrianjanaka,

David G. I. Kingston

Publication year - 2014

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol500775r

Subject(s) - triterpene , chemistry , plasmodium falciparum , ic50 , stereochemistry , cytotoxicity , in vitro , biochemistry , biology , malaria , medicine , alternative medicine , pathology , immunology

The new triterpene turranoic acid (1) and the new N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the nonsmall lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research