Open AccessCatalytic Stereospecific Allyl–Allyl Cross-Coupling of Internal Allyl Electrophiles with AllylB(pin)
Author(s) -
Hai Le,
Amanda Batten,
James P. Morken
Publication year - 2014
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol500456s
Subject(s) - electrophile , stereospecificity , chemistry , steric effects , catalysis , allyl chloride , enantiomer , coupling (piping) , medicinal chemistry , stereochemistry , organic chemistry , mechanical engineering , engineering
Application of internal electrophiles in catalytic stereospecific allyl-allyl cross-coupling enable the rapid construction of multisubstituted 1,5-dienes, including those with all carbon quaternary centers. Compounds with minimal steric differentiation can be synthesized with high enantiomeric excess.