Open AccessCu(I)–NHC Catalyzed Asymmetric Silyl Transfer to Unsaturated Lactams and Amides
Author(s) -
Vittorio Pace,
James Rae,
David J. Procter
Publication year - 2013
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol4033623
Subject(s) - chemistry , silylation , catalysis , enantiomer , enantioselective synthesis , combinatorial chemistry , nootropic , stereochemistry , medicinal chemistry , organic chemistry , psychology , psychiatry
The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
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