Open AccessA Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors
Author(s) -
Michael G. Brant,
Jeremy E. Wulff
Publication year - 2012
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol3027939
Subject(s) - neuraminidase , bicyclic molecule , mutation , hemagglutinin (influenza) , chemistry , virology , neuraminidase inhibitor , virus , computational biology , stereochemistry , gene , biology , biochemistry , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)
Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.