Open AccessDirect Palladium(II)-Catalyzed Synthesis of Arylamidines from Aryltrifluoroborates
Author(s) -
Jonas Sävmarker,
Jonas Rydfjord,
Johan Gising,
Luke R. Odell,
Mats Larhed
Publication year - 2012
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/ol300813c
Subject(s) - chemistry , catalysis , palladium , potassium , combinatorial chemistry , organic chemistry
A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2'-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.
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