Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp. | Zendy

DongChan Oh | Zendy; Michael Poulsen | Zendy; Cameron R. Currie | Zendy; Jon Clardy | Zendy

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Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.

Author(s) -

DongChan Oh,

Michael Poulsen,

Cameron R. Currie,

Jon Clardy

Publication year - 2011

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/ol102991d

Subject(s) - polyene , chemistry , candida albicans , lactam , streptomyces , stereochemistry , amphotericin b , antifungal , beta lactam , microbiology and biotechnology , bacteria , antibiotics , biochemistry , biology , genetics

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).

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