Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro | Zendy

Tao Yuan | Zendy; Pragati Nahar | Zendy; Meenakshi Sharma | Zendy; Ke Liu | Zendy; Angela L. Slitt | Zendy; Haji Akber Aisa | Zendy; Navindra P. Seeram | Zendy

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Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro

Author(s) -

Tao Yuan,

Pragati Nahar,

Meenakshi Sharma,

Ke Liu,

Angela L. Slitt,

Haji Akber Aisa,

Navindra P. Seeram

Publication year - 2014

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np500398m

Subject(s) - nigella sativa , ampk , indazole , in vitro , protein kinase a , chemistry , amp activated protein kinase , biochemistry , kinase , traditional medicine , stereochemistry , medicine

Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.

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