Identification and Bioactivity of 3-epi-Xestoaminol C Isolated from the New Zealand Brown Alga Xiphophora chondrophylla | Zendy

Nathaniel Dasyam | Zendy; Andrew B. Munkacsi | Zendy; Nazmi Harith-Fadzilah | Zendy; Dinindu Senanayake | Zendy; Ronan O’Toole | Zendy; Robert A. Keyzers | Zendy

Open Access

Identification and Bioactivity of 3-epi-Xestoaminol C Isolated from the New Zealand Brown Alga Xiphophora chondrophylla

Author(s) -

Nathaniel Dasyam,

Andrew B. Munkacsi,

Nazmi Harith-Fadzilah,

Dinindu Senanayake,

Ronan O’Toole,

Robert A. Keyzers

Publication year - 2014

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np500171z

Subject(s) - brown algae , isolation (microbiology) , bioassay , yeast , biology , absolute configuration , stereochemistry , botany , chemistry , algae , biochemistry , microbiology and biotechnology , genetics

We report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.

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