Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin | Zendy

Philipp Fruhmann | Zendy; Hannes Mikula | Zendy; Gerlinde Wiesenberger | Zendy; Elisabeth Varga | Zendy; Daniel Lumpi | Zendy; Berthold Stöger | Zendy; Georg Häubl | Zendy; Marc Lemmens | Zendy; Franz Berthiller | Zendy; Rudolf Krska | Zendy; Gerhard Adam | Zendy; Christian Hametner | Zendy; Johannes Fröhlich | Zendy

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Isolation and Structure Elucidation of Pentahydroxyscirpene, a Trichothecene Fusarium Mycotoxin

Author(s) -

Philipp Fruhmann,

Hannes Mikula,

Gerlinde Wiesenberger,

Elisabeth Varga,

Daniel Lumpi,

Berthold Stöger,

Georg Häubl,

Marc Lemmens,

Franz Berthiller,

Rudolf Krska,

Gerhard Adam,

Christian Hametner,

Johannes Fröhlich

Publication year - 2013

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np4008365

Subject(s) - trichothecene , fusarium , mycotoxin , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , toxin , chemistry , sesquiterpene , biology , botany , biochemistry , food science

Pentahydroxyscirpene, a novel trichothecene-type compound, was isolated from Fusarium-inoculated rice. The structure of pentahydroxyscirpene was elucidated by 1D and 2D NMR spectroscopy and X-ray single-crystal diffraction. The conformation in solution was determined by NOESY experiments supported by quantum chemical calculations. In vitro toxicity tests showed that pentahydroxyscirpene inhibits protein synthesis as do other trichothecenes.

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