Chlorinated Iridoid Glucosides from Veronica longifolia and Their Antioxidant Activity | Zendy

Søren Rosendal Jensen | Zendy; Charlotte H. Gotfredsen | Zendy; Ü. Şebnem Harput | Zendy; İclal Saraçoğlu | Zendy

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Chlorinated Iridoid Glucosides from Veronica longifolia and Their Antioxidant Activity

Author(s) -

Søren Rosendal Jensen,

Charlotte H. Gotfredsen,

Ü. Şebnem Harput,

İclal Saraçoğlu

Publication year - 2010

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/np100366k

Subject(s) - catalpol , iridoid , chemistry , stereochemistry , epimer , superoxide , glucoside , nitric oxide , antioxidant , organic chemistry , glycoside , enzyme , medicine , alternative medicine , pathology

From Veronica longifolia were isolated three chlorinated iridoid glucosides, namely, asystasioside E (6) and its 6-O-esters 6a and 6b, named longifoliosides A and B, respectively. The structures of 6a and 6b were proved by analysis of their spectroscopic data and by conversion to the catalpol ester verproside (5a) or to catalpol (5), respectively. The configuration of the previously known vanilloyl analogue, urphoside B, was shown to be the 6β-epimer (6c) of the structure originally reported. Longifoliosides A (6a) and B (6b) were found to exhibit radical-scavenging activity against nitric oxide, superoxide, and 2,2-diphenyl-1-picrylhydrazyl radicals.

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