Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes | Zendy

Supratim Ghosh | Zendy; Samrat Dutta | Zendy; Evan Gomes | Zendy; David Carroll | Zendy; Ralph B. D’Agostino | Zendy; John D. Olson | Zendy; Martin Guthold | Zendy; William H. Gmeiner | Zendy

Open Access

Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes

Author(s) -

Supratim Ghosh,

Samrat Dutta,

Evan Gomes,

David Carroll,

Ralph B. D’Agostino,

John D. Olson,

Martin Guthold,

William H. Gmeiner

Publication year - 2009

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/nn900368b

Subject(s) - irradiation , materials science , carbon nanotube , in vivo , laser , ablation , laser ablation , dna , nanoparticle , nanotechnology , biomedical engineering , biophysics , chemistry , optics , biochemistry , medicine , physics , microbiology and biotechnology , engineering , aerospace engineering , nuclear physics , biology

Nanoparticles, including multiwalled carbon nanotubes (MWNTs), strongly absorb near-infrared (nIR) radiation and efficiently convert absorbed energy to released heat which can be used for localized hyperthermia applications. We demonstrate for the first time that DNA-encasement increases heat emission following nIR irradiation of MWNTs, and DNA-encased MWNTs can be used to safely eradicate a tumor mass in vivo. Upon irradiation of DNA-encased MWNTs, heat is generated with a linear dependence on irradiation time and laser power. DNA-encasement resulted in a 3-fold reduction in the concentration of MWNTs required to impart a 10 degrees C temperature increase in bulk solution temperature. A single treatment consisting of intratumoral injection of MWNTs (100 microL of a 500 microg/mL solution) followed by laser irradiation at 1064 nm, 2.5 W/cm(2) completely eradicated PC3 xenograft tumors in 8/8 (100%) of nude mice. Tumors that received only MWNT injection or laser irradiation showed growth rates indistinguishable from nontreated control tumors. Nonmalignant tissues displayed no long-term damage from treatment. The results demonstrate that DNA-encased MWNTs are more efficient at converting nIR irradiation into heat compared to nonencased MWNTs and that DNA-encased MWNTs can be used safely and effectively for the selective thermal ablation of malignant tissue in vivo.

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