Targeted Therapeutic Nanotubes Influence the Viscoelasticity of Cancer Cells to Overcome Drug Resistance | Zendy

Ashwinkumar Bhirde | Zendy; Bhaskara V. Chikkaveeraiah | Zendy; Avinash Srivatsan | Zendy; Gang Niu | Zendy; Albert J. Jin | Zendy; Ankur Kapoor | Zendy; Zhe Wang | Zendy; Sachin Patel | Zendy; Vyomesh Patel | Zendy; Alexander M. Gorbach | Zendy; Richard D. Leapman | Zendy; J. Silvio Gutkind | Zendy; Angela R. Hight Walker | Zendy; Xiaohong Chen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Targeted Therapeutic Nanotubes Influence the Viscoelasticity of Cancer Cells to Overcome Drug Resistance

Author(s) -

Ashwinkumar Bhirde,

Bhaskara V. Chikkaveeraiah,

Avinash Srivatsan,

Gang Niu,

Albert J. Jin,

Ankur Kapoor,

Zhe Wang,

Sachin Patel,

Vyomesh Patel,

Alexander M. Gorbach,

Richard D. Leapman,

J. Silvio Gutkind,

Angela R. Hight Walker,

Xiaohong Chen

Publication year - 2014

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/nn501223q

Subject(s) - doxorubicin , multiple drug resistance , cancer cell , drug resistance , drug , drug delivery , pharmacology , chemistry , cancer , hyaluronic acid , peg ratio , chemotherapy , cancer research , materials science , nanotechnology , medicine , antibiotics , biochemistry , biology , finance , anatomy , microbiology and biotechnology , economics

Resistance to chemotherapy is the primary cause of treatment failure in over 90% of cancer patients in the clinic. Research in nanotechnology-based therapeutic alternatives has helped provide innovative and promising strategies to overcome multidrug resistance (MDR). By targeting CD44-overexpressing MDR cancer cells, we have developed in a single-step a self-assembled, self-targetable, therapeutic semiconducting single-walled carbon nanotube (sSWCNT) drug delivery system that can deliver chemotherapeutic agents to both drug-sensitive OVCAR8 and resistant OVCAR8/ADR cancer cells. The novel nanoformula with a cholanic acid-derivatized hyaluronic acid (CAHA) biopolymer wrapped around a sSWCNT and loaded with doxorubicin (DOX), CAHA-sSWCNT-DOX, is much more effective in killing drug-resistant cancer cells compared to the free DOX and phospholipid PEG (PL-PEG)-modified sSWCNT formula, PEG-sSWCNT-DOX. The CAHA-sSWCNT-DOX affects the viscoelastic property more than free DOX and PL-PEG-sSWCNT-DOX, which in turn allows more drug molecules to be internalized. Intravenous injection of CAHA-sSWCNT-DOX (12 mg/kg DOX equivalent) followed by 808 nm laser irradiation (1 W/cm(2), 90 s) led to complete tumor eradication in a subcutaneous OVCAR8/ADR drug-resistant xenograft model, while free DOX alone failed to delay tumor growth. Our newly developed CAHA-sSWCNT-DOX nanoformula, which delivers therapeutics and acts as a sensitizer to influence drug uptake and induce apoptosis with minimal resistance factor, provides a novel effective means of counteracting the phenomenon of multidrug resistance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research