Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein | Zendy

Manoj K. Gottipati | Zendy; Elena Bekyarova | Zendy; Michael Brenner | Zendy; Robert C. Haddon | Zendy; Vladimir Parpura | Zendy

Open Access

Changes in the Morphology and Proliferation of Astrocytes Induced by Two Modalities of Chemically Functionalized Single-Walled Carbon Nanotubes are Differentially Mediated by Glial Fibrillary Acidic Protein

Author(s) -

Manoj K. Gottipati,

Elena Bekyarova,

Michael Brenner,

Robert C. Haddon,

Vladimir Parpura

Publication year - 2014

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/nl4048114

Subject(s) - glial fibrillary acidic protein , gfap stain , carbon nanotube , astrocyte , morphology (biology) , biophysics , microbiology and biotechnology , chemistry , cell growth , materials science , nanotechnology , biology , biochemistry , neuroscience , immunology , immunohistochemistry , central nervous system , genetics

Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films.

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