Open AccessThe HCV Revolution Did Not Happen Overnight
Author(s) -
Ann D. Kwong
Publication year - 2014
Publication title -
acs medicinal chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 66
ISSN - 1948-5875
DOI - 10.1021/ml500070q
Subject(s) - pill , medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , hepatitis c , antiviral therapy , intensive care medicine , family medicine , pharmacology , virology , viral load , chronic hepatitis , virus
The progress in HCV therapy in the last three years is similar to the progress that took HIV therapy ∼14 years. We are at the brink of approval for an all-oral drug combination that is dosed once daily as a single pill, has >95% efficacy, and is well tolerated. This article summarizes the path to this success and the challenges still ahead.