Open AccessDigitoxin Analogues with Improved Anticytomegalovirus Activity
Author(s) -
Hongyi Cai,
Hua Yu L. Wang,
Rajkumar Venkatadri,
Dax Fu,
Michael Forman,
Sumit O. Bajaj,
Hongyan Li,
George A. O’Doherty,
Ravit AravBoger
Publication year - 2014
Publication title -
acs medicinal chemistry letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 66
ISSN - 1948-5875
DOI - 10.1021/ml400529q
Subject(s) - digitoxin , glycoside , sugar , chemistry , pharmacology , structure–activity relationship , biochemistry , stereochemistry , biology , medicine , in vitro , digoxin , heart failure
Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.