Open AccessCu-Catalyzed Direct Amidation of Aromatic C–H Bonds: An Access to Arylamines
Author(s) -
Hui Xu,
Xixue Qiao,
Shiping Yang,
Zengming Shen
Publication year - 2014
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/jo5003592
Subject(s) - chemistry , phthalimide , amination , catalysis , substrate (aquarium) , combinatorial chemistry , organic chemistry , oceanography , geology
A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.
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