Palladium-Catalyzed Multicomponent Synthesis of 2-Aryl-2-imidazolines from Aryl Halides and Diamines | Zendy

Joanna V. Geden | Zendy; Alpa K. Pancholi | Zendy; Michael Shipman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Palladium-Catalyzed Multicomponent Synthesis of 2-Aryl-2-imidazolines from Aryl Halides and Diamines

Author(s) -

Joanna V. Geden,

Alpa K. Pancholi,

Michael Shipman

Publication year - 2013

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/jo400252n

Subject(s) - chemistry , aryl , palladium , catalysis , halide , component (thermodynamics) , diamine , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl , physics , thermodynamics

An efficient palladium-catalyzed three-component reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-imidazolines in yields up to 96%. Through variation of the diamine component, the reaction can be extended to the synthesis of 2-aryl-1H-benzimidazoles and 2-aryl-1,4,5,6-tetrahydropyrimidines.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research