Open AccessDesign, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid
Author(s) -
Li Chen,
Yihua Zhang,
Xiangbin Kong,
Edward Lan,
Zhangjian Huang,
Sixun Peng,
Daniel L. Kaufman,
Jide Tian
Publication year - 2008
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/jm800167u
Subject(s) - furoxan , oleanolic acid , chemistry , nitric oxide , in vivo , in vitro , hepatocellular carcinoma , cytotoxicity , pharmacology , nitric acid , biological activity , cancer research , biochemistry , organic chemistry , pathology , medicine , biology , alternative medicine , microbiology and biotechnology
Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in vitro. Treatment with 8b or 16b significantly inhibited the growth of HCC tumors in vivo. These data provide a proof-in-principle that furoxan/OA hybrids may be used for therapeutic intervention of human liver cancers.