A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes | Zendy

Fionn O’Hara | Zendy; Aaron C. Burns | Zendy; Michael R. Collins | Zendy; Deepak Dalvie | Zendy; Martha A. Ornelas | Zendy; Alfin D. N. Vaz | Zendy; Yuta Fujiwara | Zendy; Phil S. Baran | Zendy

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Author(s) -

Fionn O’Hara,

Aaron C. Burns,

Michael R. Collins,

Deepak Dalvie,

Martha A. Ornelas,

Alfin D. N. Vaz,

Yuta Fujiwara,

Phil S. Baran

Publication year - 2014

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/jm4017976

Subject(s) - litmus , chemistry , aldehyde oxidase , aldehyde , in vivo , bioavailability , metabolism , drug metabolism , biochemistry , combinatorial chemistry , stereochemistry , organic chemistry , enzyme , pharmacology , biology , microbiology and biotechnology , xanthine oxidase , catalysis

The bioavailability of aromatic azaheterocyclic drugs can be affected by the activity of aldehyde oxidase (AO). Susceptibility to AO metabolism is difficult to predict computationally and can be complicated in vivo by differences between species. Here we report the use of bis(((difluoromethyl)sulfinyl)oxy)zinc (DFMS) as a source of CF2H radical for a rapid and inexpensive chemical "litmus test" for the early identification of heteroaromatic drug candidates that have a high probability of metabolism by AO.

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