Open AccessMultimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine
Author(s) -
Elizabeth Neumann,
Katerina Djambazova,
Richard M. Caprioli,
Jeffrey M. Spraggins
Publication year - 2020
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1021/jasms.0c00232
Subject(s) - mass spectrometry imaging , mass spectrometry , molecular imaging , nanotechnology , maldi imaging , chemistry , medical imaging , computational biology , data science , computer science , artificial intelligence , materials science , matrix assisted laser desorption/ionization , chromatography , biology , microbiology and biotechnology , organic chemistry , adsorption , desorption , in vivo
Imaging mass spectrometry has become a mature molecular mapping technology that is used for molecular discovery in many medical and biological systems. While powerful by itself, imaging mass spectrometry can be complemented by the addition of other orthogonal, chemically informative imaging technologies to maximize the information gained from a single experiment and enable deeper understanding of biological processes. Within this review, we describe MALDI, SIMS, and DESI imaging mass spectrometric technologies and how these have been integrated with other analytical modalities such as microscopy, transcriptomics, spectroscopy, and electrochemistry in a field termed multimodal imaging. We explore the future of this field and discuss forthcoming developments that will bring new insights to help unravel the molecular complexities of biological systems, from single cells to functional tissue structures and organs.