Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids | Zendy

Yongpeng Yao | Zendy; Chunyan An | Zendy; Declan Evans | Zendy; Weiwei Liu | Zendy; Wei Wang | Zendy; Guangzheng Wei | Zendy; Ning Ding | Zendy; K. N. Houk | Zendy; ShuShan Gao | Zendy

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Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids

Author(s) -

Yongpeng Yao,

Chunyan An,

Declan Evans,

Weiwei Liu,

Wei Wang,

Guangzheng Wei,

Ning Ding,

K. N. Houk,

ShuShan Gao

Publication year - 2019

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.9b10217

Subject(s) - chemistry , catalase , oxidative phosphorylation , stereochemistry , organic chemistry , biochemistry , enzyme

A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O 2 as the oxidant, that catalyzes the oxidative cyclization of the central C ring from a 1,3-diene intermediate. Our study showcases how nature evolves the common catalase for enantioselective C-C bond construction of complex polycyclic scaffolds.

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