Hydroalkylation of Olefins To Form Quaternary Carbons | Zendy

Samantha A. Green | Zendy; Tucker R. Huffman | Zendy; Ruairí O. McCourt | Zendy; Vincent A. van der Puyl | Zendy; Ryan A. Shenvi | Zendy

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Hydroalkylation of Olefins To Form Quaternary Carbons

Author(s) -

Samantha A. Green,

Tucker R. Huffman,

Ruairí O. McCourt,

Vincent A. van der Puyl,

Ryan A. Shenvi

Publication year - 2019

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.9b02844

Subject(s) - chemistry , markovnikov's rule , electrophile , alkyl , hydride , halide , catalysis , selectivity , quaternary carbon , alkylation , organic chemistry , combinatorial chemistry , medicinal chemistry , metal , enantioselective synthesis , regioselectivity

Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp 3 electrophiles have been reported. Here we describe a Mn/Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary carbons.

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