Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy | Zendy

Wasim M. Akhtar | Zendy; Roly J. Armstrong | Zendy; James R. Frost | Zendy; Neil G. Stevenson | Zendy; Timothy J. Donohoe | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy

Author(s) -

Wasim M. Akhtar,

Roly J. Armstrong,

James R. Frost,

Neil G. Stevenson,

Timothy J. Donohoe

Publication year - 2018

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.8b07776

Subject(s) - cyclohexanes , chemistry , stereoselectivity , annulation , iridium , catalysis , cyclohexane , combinatorial chemistry , cyclopentanes , organic chemistry

An iridium catalyzed method for the synthesis of functionalized cyclohexanes from methyl ketones and 1,5-diols is described. This process operates by two sequential hydrogen borrowing reactions, providing direct access to multisubstituted cyclic products with high levels of stereocontrol. This methodology represents a novel (5 + 1) strategy for the stereoselective construction of the cyclohexane core.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research