Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection | Zendy

Laura RodríguezPérez | Zendy; Javier RamosSoriano | Zendy; Alfonso PérezSánchez | Zendy; Beatriz M. Illescas | Zendy; Antonio Muñoz | Zendy; Joanna Luczkowiak | Zendy; Fátima Lasala | Zendy; Javier Rojo | Zendy; Rafaël Delgado | Zendy; Nazario Martı́n | Zendy

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Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Author(s) -

Laura RodríguezPérez,

Javier RamosSoriano,

Alfonso PérezSánchez,

Beatriz M. Illescas,

Antonio Muñoz,

Joanna Luczkowiak,

Fátima Lasala,

Javier Rojo,

Rafaël Delgado,

Nazario Martı́n

Publication year - 2018

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.8b03847

Subject(s) - chemistry , glycoconjugate , ebola virus , virus , viral infection , click chemistry , covalent bond , virology , combinatorial chemistry , nanotechnology , biochemistry , organic chemistry , materials science , biology

SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

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