Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts | Zendy

Cristina GarcíaMorales | Zendy; Beatrice Ranieri | Zendy; Imma Escofet | Zendy; Laura López-Suárez | Zendy; Carla Obradors | Zendy; Andrey I. Konovalov | Zendy; Antonio M. Echavarren | Zendy

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Enantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C₂ Symmetric Digold Catalysts

Author(s) -

Cristina GarcíaMorales,

Beatrice Ranieri,

Imma Escofet,

Laura López-Suárez,

Carla Obradors,

Andrey I. Konovalov,

Antonio M. Echavarren

Publication year - 2017

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.7b07651

Subject(s) - enantioselective synthesis , chemistry , cycloaddition , intermolecular force , catalysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , molecule

The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C 2 -chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has been applied to the enantioselective total synthesis of rumphellaone A.

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