Open AccessEnantioselective Synthesis of Cyclobutenes by Intermolecular [2+2] Cycloaddition with Non-C2 Symmetric Digold Catalysts
Author(s) -
Cristina GarcíaMorales,
Beatrice Ranieri,
Imma Escofet,
Laura López-Suárez,
Carla Obradors,
А. И. Коновалов,
Antonio M. Echavarren
Publication year - 2017
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.7b07651
Subject(s) - enantioselective synthesis , chemistry , cycloaddition , intermolecular force , catalysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , molecule
The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C 2 -chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has been applied to the enantioselective total synthesis of rumphellaone A.