Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity | Zendy

Daniel E. Mitchell | Zendy; Guy J. Clarkson | Zendy; David J. Fox | Zendy; Rebecca Ann Vipond | Zendy; Peter Scott | Zendy; Matthew I. Gibson | Zendy

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Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity

Author(s) -

Daniel E. Mitchell,

Guy J. Clarkson,

David J. Fox,

Rebecca Ann Vipond,

Peter Scott,

Matthew I. Gibson

Publication year - 2017

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.7b05822

Subject(s) - chemistry , antifreeze protein , recrystallization (geology) , antifreeze , biophysics , biochemistry , organic chemistry , paleontology , biology

Antifreeze proteins are produced by extremophile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just 20 μM. Structure-property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.

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