Open AccessRuthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration
Author(s) -
Takuma Watanabe,
Yuichiro Mutoh,
Shinichi Saito
Publication year - 2017
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.7b04564
Subject(s) - cycloisomerization , ruthenium , chemistry , catalysis , carbon fibers , organic chemistry , medicinal chemistry , materials science , composite material , composite number
We developed ruthenium-catalyzed cycloisomerization of alkynylanilides that gave 3-substituted indoles in high yields. The reaction proceeded via the disubstituted vinylidene ruthenium complex that was formed by the 1,2-carbon migration.
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