Open AccessStrain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity
Author(s) -
Justin M. Lopchuk,
Kasper Fjelbye,
Yu Kawamata,
Lara R. Malins,
ChungMao Pan,
Ryan Gianatassio,
Jie Wang,
Liher Prieto,
James Bradow,
Thomas A. Brandt,
Michael R. Collins,
Jeff Elleraas,
Jason Ewanicki,
William Farrell,
Olugbeminiyi O. Fadeyi,
Gary M. Gallego,
James J. Mousseau,
Robert M. Oliver,
Neal W. Sach,
Jason K Smith,
Jillian E. Spangler,
Huichin Zhu,
JinJiang Zhu,
Phil S. Baran
Publication year - 2017
Publication title -
journal of the american chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.115
H-Index - 612
eISSN - 1520-5126
pISSN - 0002-7863
DOI - 10.1021/jacs.6b13229
Subject(s) - bioconjugation , chemistry , chemical space , heteroatom , combinatorial chemistry , surface modification , stereospecificity , reagent , organic chemistry , drug discovery , ring (chemistry) , catalysis , biochemistry
Driven by the ever-increasing pace of drug discovery and the need to push the boundaries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained bioisosteres such as bicyclo[1.1.1]pentane, azetidine, and cyclobutane to modify their lead compounds. Too often, however, the difficulty of installing these fragments surpasses the challenges posed even by the construction of the parent drug scaffold. This full account describes the development and application of a general strategy where spring-loaded, strained C-C and C-N bonds react with amines to allow for the "any-stage" installation of small, strained ring systems. In addition to the functionalization of small building blocks and late-stage intermediates, the methodology has been applied to bioconjugation and peptide labeling. For the first time, the stereospecific strain-release "cyclopentylation" of amines, alcohols, thiols, carboxylic acids, and other heteroatoms is introduced. This report describes the development, synthesis, scope of reaction, bioconjugation, and synthetic comparisons of four new chiral "cyclopentylation" reagents.