Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies | Zendy

Harriet J. Clarke | Zendy; Ethan N. W. Howe | Zendy; Xin Wu | Zendy; Fabian Sommer | Zendy; Masafumi Yano | Zendy; Mark E. Light | Zendy; Stefan Kubik | Zendy; Philip A. Gale | Zendy

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Transmembrane Fluoride Transport: Direct Measurement and Selectivity Studies

Author(s) -

Harriet J. Clarke,

Ethan N. W. Howe,

Xin Wu,

Fabian Sommer,

Masafumi Yano,

Mark E. Light,

Stefan Kubik,

Philip A. Gale

Publication year - 2016

Publication title -

journal of the american chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.6b10694

Subject(s) - chemistry , selectivity , fluoride , transmembrane protein , inorganic chemistry , organic chemistry , biochemistry , receptor , catalysis

Fluoride has been overlooked as a target in the development of synthetic anion transporters despite natural fluoride transport channels being recently discovered. In this paper we report the direct measurement of fluoride transport across lipid bilayers facilitated by a series of strapped calix[4]pyrroles and show that these compounds facilitate transport via an electrogenic mechanism (determined using valinomycin and monensin coupled transport assays and an additional osmotic response assay). An HPTS transport assay was used to quantify this electrogenic process and assess the interference of naturally occurring fatty acids with the transport process and Cl - over H + /OH - ransport selectivity.

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