Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling | Zendy

Samantha A. Green | Zendy; Jeishla L. M. Matos | Zendy; Akiko Yagi | Zendy; Ryan A. Shenvi | Zendy

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Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling

Author(s) -

Samantha A. Green,

Jeishla L. M. Matos,

Akiko Yagi,

Ryan A. Shenvi

Publication year - 2016

Publication title -

journal of the american chemical society

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.115

H-Index - 612

eISSN - 1520-5126

pISSN - 0002-7863

DOI - 10.1021/jacs.6b08507

Subject(s) - chemistry , olefin fiber , nickel , catalysis , markovnikov's rule , ring (chemistry) , catalytic cycle , coupling (piping) , hydrogen atom , cobalt , photochemistry , organic chemistry , regioselectivity , metallurgy , materials science , alkyl

A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.

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